The filter of drug dissolution meter is an important part in drug quality control (QC) and drug development. When a sample is removed from the dissolution container, the dissolution test determines the rate at which the drug is released from the dosage form by measuring the amount of active pharmaceutical ingredient (API) dissolved at a specific point in time.
Filtration plays a key role in dissolution test. The efficiency of the filter of drug dissolution meter depends on the size of undissolved drug particles. It can stir the sample to promote the dissolution of drug particles. The use of filter can effectively prevent drug particles from entering the pipeline system and avoid the experimental error caused by the difference of sampling height.
For example, the on-line filter of the uHPLCs stainless steel dissolution instrument has no adsorption on the sample, which is very important for drug analysis. In addition, the uHPLCs dissolution instrument filter adopts a novel full flow filter design to ensure the integrity of your dissolved sample, provide a higher surface area, prolong the service life of the filter and prevent blockage during sampling.
Of course, sample preparation and effective filtration are very helpful to obtain accurate results, but we should also pay attention to the protection of expensive analytical equipment in the analysis. Downstream analysis is usually performed by HPLC or UV-VIS spectrophotometry, so some residual impurities may damage and potentially clog the HPLC column.
Some impurities may contaminate the column head of liquid chromatography, causing the collapse of packing and eventually damaging the column. There are thousands to tens of thousands of pieces of a column. You should also pay attention to maintenance when using it. The chromatographic protective column is an effective means to effectively protect the chromatographic column from chemical pollution. The protective column is added in front of the column to effectively filter the metal ions and pollutants in the system and maintain the efficiency of the chromatographic analysis column.
When choosing the filter for dissolution tester, note that:
Multiple factors affect the effectiveness of sample filtration and the accuracy and consistency of subsequent analysis. The filter section must consider the solvents used, the API, and your methods, equipment, and workflow. For HPLC analyses, chemical compatibility and low levels of extractable matter are always important considerations to reduce the risk of new contaminants interfering with the results. For example, if chemical compatibility is not ideal, use ultra high molecular weight polyethylene (UHMWPE) or polyvinylidene fluoride (PVDF) material filters.
Post time: Mar-29-2022
